2-Trifluoromethylthiazole-5-carboxylic acid ethyl ester

2-Trifluoromethylthiazole-5-carboxylic acid ethyl ester - Names and Identifiers

Name	ethyl 2-(trifluoromethyl)-1,3-thiazole-5-carboxylate
Synonyms	ethyl 2-(trifluoroMethyl)-1,3-thiazole-5-ca ethyl 2-(trifluoroMethyl)thiazol-5-carboxylate ETHYL 2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE 2-trifluoroMethylthiozole-5-carboxylic acid ethyl ethyl 2-(trifluoromethyl)-1,3-thiazole-5-carboxylate Ethyl 2-(trifluoromethyl)-1,3-thiazole-5-carboxylate ethyl 2-(trifluoroMethyl)-1,3-thiazole-5-carboxylate 2-Trifluoromethylthiazole-5-carboxylic acid ethyl ester 2-(Trifluoromethyl)-5-thiazolecarboxylic acid ethyl ester 5-Thiazolecarboxylic acid, 2-(trifluoromethyl)-, ethyl ester
CAS	131748-96-4
InChI	InChI=1/C7H6F3NO2S/c1-2-13-5(12)4-3-11-6(14-4)7(8,9)10/h3H,2H2,1H3
InChIKey	KQTWGECEHUVSPX-UHFFFAOYSA-N

2-Trifluoromethylthiazole-5-carboxylic acid ethyl ester - Physico-chemical Properties

Molecular Formula	C7H6F3NO2S
Molar Mass	225.19
Density	1.407
Boling Point	195℃
Flash Point	72℃
Vapor Presure	0.433mmHg at 25°C
pKa	-2.02±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	n20/D1.441
Use	This product is for scientific research only and shall not be used for other purposes.

2-Trifluoromethylthiazole-5-carboxylic acid ethyl ester - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves.
UN IDs	NA 1993 / PGIII
WGK Germany	3
HS Code	29349990

2-Trifluoromethylthiazole-5-carboxylic acid ethyl ester - Introduction

Ethyl 2-(trifluoromethyl) thiazole-5-carboxylate, also known as TFMT, is an organic compound. The compound has the molecular formula C7H5F3N2OS and the structural formula CF3CSN(CH3)OCOCH3.

TFMT is a colorless liquid with a strong pungent odor. It is soluble in organic solvents such as diethyl ether, methanol and dichloromethane.

The main use of TFMT is as a catalyst and reagent in organic synthesis. It can be used to synthesize drugs, pesticides, dyes and other organic compounds. TFMT can promote esterification reactions, condensation reactions, and reactions of alkynes and aromatic compounds, etc.

TFMT is generally prepared by reacting trifluoromethanethiol with ethyl 2-thiazole-5-carboxylate. In the laboratory, this can be accomplished by adding an excess of trifluoromethanethiol to the ethyl 2-thiazole-5-carboxylate reaction mixture and reacting at low temperature.

Regarding the safety information of TFMT, due to its irritation and corrosiveness, you need to pay attention to safety when using it. Avoid contact with skin and eyes during operation, and maintain good ventilation. TFMT also has a certain toxicity, so it needs to be used under safe laboratory conditions. In case of accidental contact, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 20:49:11